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This might be targeting angiogenesis and NO’s cytotoxic and damaging actions but maintaining, promoting, or recovering their essential protective functions

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Tirzepatide engages GIP near the strength of the natural hormone but activates GLP-1 about 18 times more weakly than natural GLP-1.⁷ After accounting for protein binding in blood, the drug is roughly 20-fold GIP-forward and has no meaningful glucagon activity